Epitalon Rx
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Compounded, not FDA-approved

Almost everything known about epitalon comes from the laboratory that invented it

Of the 167 papers indexed on this peptide, 111 carry Vladimir Khavinson or Vladimir Anisimov as an author or name the St. Petersburg Institute of Bioregulation and Gerontology. That is 66.5 percent, and Khavinson alone is on 100 of them. It is not a conspiracy and it is not a smear: that institute created the compound and has published on it for four decades. It does mean the test medicine actually applies, someone with no stake in the answer getting the same result, has been applied here only recently and only in cells. The mortality figures everyone quotes are about Epithalamin, a pineal extract, not the tetrapeptide in the vial. Zero records in the epitalon literature carry a randomized-trial tag; the extract's literature has five. In July 2026 FDA proposed that epitalon not even be allowed into compounded drugs. Every row in our evidence table is labeled by species and by who ran it.

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  • 66.5percent of the indexed literature comes from the research network that created epitalon
  • 167papers indexed on this peptide in Europe PMC
  • 0carry a randomized-controlled-trial tag, against 5 in the literature on the pineal extract it is confused with
  • 32rows in our evidence table, each labeled by species and by provenance, including 5 documented absences
  • 0studies from any laboratory outside that network in which epitalon was given to a person
  • 45fetch-verified citations, 86.7 percent of them peer-reviewed or government sources

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Compounded injectable treatmentPrepared after approval
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Key facts

  • StatusCompounded, not FDA-approved
  • Human half-lifeNot establishedsource
  • Human subcutaneous bioavailabilityNot establishedsource
  • Human Cmax or AUCNot establishedsource
  • Published human PK studies0source
  • Registered clinical trials0source
  • ClassSynthetic pineal tetrapeptide, derived from the pineal peptide extract EpithalaminChemical referencesource
  • SequenceAla-Glu-Asp-Gly (AEDG)Chemical referencesource
  • Molecular weight390.35 Da (C14H22N4O9)Chemical referencesource
  • CAS307297-39-8Chemical referencesource
  • US FDA statusNot approved for any use; listed on FDA's compounding safety-risks page under substances nominated but withdrawnRegulatory recordsource
  • July 2026 PCACFDA proposed Epitalon (free base) and Epitalon acetate NOT be added to the 503A Bulks ListRegulatory recordsource
  • Provenance concentration111 of 167 indexed records (66.5 percent) come from the originating research networkAnalytical studysource
  • Khavinson as author100 of 167 records (59.9 percent)Analytical studysource
  • Independent human studies0Absence of evidencesource
  • Randomized trials of epitalon0 (the epithalamin extract literature has 5)Absence of evidencesource
  • Meta-analyses and systematic reviews0Absence of evidencesource
  • Registered trials (ClinicalTrials.gov)0Absence of evidencesource
  • Human pharmacokineticsNone publishedAbsence of evidencesource
  • Established human doseNone; published regimens disagree by up to four orders of magnitudeAbsence of evidencesource
  • Indexed literature167 Europe PMC records; 52 Russian-languageAnalytical studysource
  • Independent in vitro replicationYes, Brunel University London, 2025, 22 years after the original claimIn vitrosource
  • Best rodent lifespan resultNo change in mean lifespan; maximum lifespan plus 12.3 percentAnimalsource
  • Route as soldSubcutaneous injection after reconstitution of a lyophilized vialReview or guidelinesource

Read the full Epitalon monograph

Browse by topic

Everything on Epitalon (epithalon), organized the way you research it.

Evidence19 articlesSourcing10 articlesSafety8 articlesDosing7 articlesComparisons6 articles

Free Epitalon tools

Practical calculators and references, each scoped and sourced.

Review-gated tools: these tools are excluded from search and AI citation and must not be used as dosing, reconstitution, injection, longevity, or treatment instruction.

T-01Epitalon reconstitution calculator (no-label model)Work out the concentration of a reconstituted epitalon vial, the volume to draw for a given quantity, the equivalent mark on a U-100 insulin syringe, and how many of those quantities a vial contains. It is the arithmetic a buyer actually performs, done correctly and labeled honestly: every output carries forward the fact that the vial strength was never verified by anyone.T-03Epitalon study dose explorerThe per-compound data component: every epitalon and epithalamin regimen this site could verify in the published literature, filterable by species, substance, study design, provenance and whether the study's primary endpoint was null. Each row shows the design the source actually describes and links to the study. It answers the question a calculator cannot: not how much to draw, but what was actually given, to what, in what kind of study, by whom, and whether it worked.

All guides

50 in-depth, individually cited guides.

Review-gated archive: the guides below are preserved for individual medical and source review. They are excluded from search indexing and AI citation files.

Evidence 19 guides

Epitalon alternatives: what the evidence actually supportsEpitalon's telomerase claims trace to one Russian lab. Here's how NAD+ boosters, TA-65, and other peptides compare on real human evidence in 2026.Updated 2026-07-30Read guide →
Epitalon cost per month: what it actually runs in 2026Epitalon runs roughly $150-$450 per month depending on dose, cycle length, and source. Here's the real math, provider costs, and where the evidence actually stands.Updated 2026-07-30Read guide →
Epitalon first month: what to expect week by weekA realistic week-by-week guide to an epitalon first month: dosing schedules, sleep and energy reports, and why the telomerase claims still rest on rodent data.Updated 2026-07-30Read guide →
Epitalon FAQ: what the evidence actually showsStraight answers on epitalon's telomerase claims, the Khavinson research base, dosing, safety and spelling. What's proven in rodents vs. humans.Updated 2026-07-30Read guide →
Epitalon in older adults: what the evidence actually showsEpitalon's telomerase and lifespan data come from small Russian studies, mostly rodents and elderly patients decades ago. Here's what's solid and what isn't.Updated 2026-07-30Read guide →
Epitalon pros and cons: what the evidence actually showsEpitalon's telomerase claims rest on a small Russian research base, not human trials. Here's the honest pros and cons breakdown for 2026.Updated 2026-07-30Read guide →
Epitalon results timeline: what to actually expectEpitalon's timeline claims come mostly from Russian rodent studies over months, not weeks. Here's what evidence supports and what human users actually report.Updated 2026-07-30Read guide →
Epitalon telehealth options: what you actually getTelehealth epitalon means a provider consult plus a compounding pharmacy shipment, not FDA-approved treatment. Here's what's real, what costs, and what's missing.Updated 2026-07-30Read guide →
Is epitalon worth it? a buyer's reality checkEpitalon's telomerase and lifespan claims rest on Russian rodent and cohort studies, not human trials. Here's what the evidence actually supports before you buy.Updated 2026-07-30Read guide →
Epitalon animal studies vs human evidence: what's provenEpitalon's telomerase and lifespan claims rest on rodent and Russian human trials from one research group. Here's what's actually replicated and what isn't.Updated 2026-07-26Read guide →
Epitalon before and after claims: what the evidence showsEpitalon's telomerase and lifespan claims trace to a small Russian research group, mostly rodent studies. No human before-and-after data exists. Here's the full evidence gap.Updated 2026-07-26Read guide →
Epitalon clinical trials: what the human evidence showsEpitalon's lifespan claims trace mostly to Russian rodent studies. Here's what human clinical trial data actually exists, and what's still missing.Updated 2026-07-26Read guide →
Epitalon human studies: what the evidence actually showsEpitalon's lifespan claims trace to a small Russian research group with limited peer review. Here's what human data exists, and what's missing.Updated 2026-07-26Read guide →
Epitalon in women: what the evidence actually showsEpitalon's telomerase and anti-aging data come mostly from Russian rodent studies. Here's what's known (and not) about how it works in women specifically.Updated 2026-07-26Read guide →
Epitalon results: what the research actually showsEpitalon's telomerase and lifespan claims trace mostly to one Russian lab. Here's what's replicated, what's rodent-only, and what's missing in humans.Updated 2026-07-26Read guide →
Epitalon stacks with other peptides: what evidence actually supportsEpitalon is often stacked with BPC-157, GHK-Cu, or growth hormone peptides. Here's what human and animal data actually say about combining them, and the risks nobody's tested.Updated 2026-07-26Read guide →
Epithalon: what the telomerase and lifespan evidence showsEpithalon's telomerase and lifespan claims trace to one Russian lab. Here's what the rodent, cell, and human data actually show, and where it stops.Updated 2026-07-26Read guide →
How long does epitalon take to work?Most epitalon users report changes at 10-20 days into a course, but human timing data doesn't exist. Here's what the rodent studies actually timed.Updated 2026-07-26Read guide →
What does Epitalon actually do in the bodyEpitalon's telomerase and lifespan claims come mostly from Russian rodent studies. Here's what's actually shown, what's extrapolated, and what's unknown.Updated 2026-07-26Read guide →

Sourcing 10 guides

Epitalon compounded vs brand name: what you're actually buyingEpitalon has no FDA-approved brand version. Every legal US source is a compounded or research peptide. Here's what that means for quality and price.Updated 2026-07-30Read guide →
Where to buy epitalon legally: a buyer's reality checkEpitalon is sold as a research chemical, not an approved drug. Here's what US law actually allows, what to check before buying, and where oversight exists.Updated 2026-07-30Read guide →
Buy epitalon: what you're actually getting, sourcing guideEpitalon peptide for sale isn't FDA-approved for any use. Here's what purity data, sourcing risk, and the actual Russian evidence base mean before you buy.Updated 2026-07-26Read guide →
Epitalon certificate of analysis explained: what to checkHow to read an epitalon certificate of analysis: purity thresholds, mass spec vs HPLC, what a COA can't tell you, and red flags in seller paperwork.Updated 2026-07-26Read guide →
Epitalon compounding pharmacy vs research supplierEpitalon from a compounding pharmacy needs a prescription and USP <797> sterility. Research suppliers sell 'not for human use' vials with no such checks. Here's the real gap.Updated 2026-07-26Read guide →
Epitalon cost and pricing: what you actually pay in 2026Epitalon runs $50 to $250 per vial depending on source and purity. Here's what drives the price, what's a red flag, and what a full cycle really costs.Updated 2026-07-26Read guide →
Epitalon prescription requirements: what US buyers faceEpitalon isn't FDA-approved for any use. There's no prescription pathway in the usual sense; here's what that actually means for buying it legally in the US.Updated 2026-07-26Read guide →
Epitalon purity and testing: what buyers should demandMost Epitalon sold online has no public COA. Learn what purity tests, HPLC/MS reports, and endotoxin limits actually mean before you buy.Updated 2026-07-26Read guide →
Epitalon storage and shelf life: how to store it rightLyophilized epitalon lasts years refrigerated or frozen; reconstituted vials hold about 2-4 weeks at 36-46°F. Here's the actual evidence behind those numbers.Updated 2026-07-26Read guide →
How to verify Epitalon quality before you buy itNo FDA-approved test kit exists for Epitalon. Here's what a real COA shows, what red flags mean, and why third-party HPLC/MS testing is the only real check.Updated 2026-07-26Read guide →

Safety 8 guides

Epitalon and antidepressants: what's known about mixing themNo published human trials test epitalon with antidepressants. Here's what the Russian peptide research actually shows, and the real interaction risks nobody has studied.Updated 2026-07-30Read guide →
Epitalon common mistakes that waste money or risk safetyMost epitalon mistakes trace to one thing: treating a rat study like a human guarantee. Here are the errors that cost buyers money and safety.Updated 2026-07-30Read guide →
Epitalon overdose and toxicity: what the evidence showsNo published human overdose threshold exists for epitalon. Here's what animal toxicity data, peptide safety norms, and dosing math actually tell you.Updated 2026-07-30Read guide →
Epitalon rebound effect: does stopping cause a crash?No published study documents an epitalon rebound effect. Human trial data is thin. Here's what the actual research says about stopping cycles and what happens after.Updated 2026-07-30Read guide →
Epitalon withdrawal and stopping: what actually happensNo withdrawal syndrome is documented for epitalon. Here's what the cycling data, Russian trials, and peptide pharmacology actually say about stopping it.Updated 2026-07-30Read guide →
Epitalon long term side effects: what the evidence showsNo human trial has tracked epitalon past a few months. Here's what's known about long term side effects, gaps in the data, and how to weigh the risk.Updated 2026-07-26Read guide →
Epitalon side effects: what the safety evidence actually showsEpitalon side effect reports are mostly mild and self-limited in small trials, but human safety data is thin. Here's what's documented and what isn't.Updated 2026-07-26Read guide →
Is Epitalon safe? What the human data actually showsEpitalon has no FDA-approved human trials on safety. Russian studies report few side effects, but independent replication is thin. Here's the real evidence.Updated 2026-07-26Read guide →

Dosing 7 guides

Epitalon dosage: protocols, cycle lengths, and what's unprovenMost cited protocols use 5-10mg/day injected for 10-20 days. Here's what the Russian source studies actually tested, and where human dosing data runs out.Updated 2026-07-26Read guide →
Epitalon dosage calculator: how to work out your doseNo validated epitalon dosage calculator exists. See the actual protocol doses (5-10mg/day) from Russian trials and how to calculate mg per vial yourself.Updated 2026-07-26Read guide →
Epitalon how to inject: reconstitution and dosing stepsEpitalon injection protocol: reconstitution ratios, subcutaneous technique, typical 10mg/day for 10-20 days. Evidence is Russian rodent/human data, not replicated.Updated 2026-07-26Read guide →
Epitalon injection sites: where and how it's injectedEpitalon is typically injected subcutaneously in the abdomen or thigh, rotated to avoid irritation. Evidence for the practice is thin. Here's what's actually documented.Updated 2026-07-26Read guide →
Epitalon peptide injections: dosing, safety, and evidenceEpitalon peptide injections: real protocol details, what the Russian telomerase studies actually show, and where the human evidence runs out.Updated 2026-07-26Read guide →
How to reconstitute epitalon: a step-by-step guideHow to reconstitute epitalon peptide with bacteriological water, storage rules, and dosing math, plus what the Russian rodent data actually shows.Updated 2026-07-26Read guide →
How to take epitalon peptide: dosing, timing, and cyclesMost protocols use 5-10mg/day subcutaneous injections for 10-20 days, but human dosing data barely exists. Here's what the actual research shows.Updated 2026-07-26Read guide →

Comparisons 6 guides

Natural alternatives to epitalon: what evidence actually supportsNo supplement matches epitalon's Russian rodent data. Here's what melatonin, NAD+ precursors, and peptide-adjacent options can and can't do.Updated 2026-07-30Read guide →
Epitalon vs metformin: how the longevity evidence comparesMetformin has decades of human trial data (UKPDS, TAME). Epitalon has rodent studies from one Russian lab group. Here's the actual evidence gap explained.Updated 2026-07-26Read guide →
Epitalon vs NAD+: how the two longevity peptides compareEpitalon and NAD+ work on different biology entirely. Compare the evidence, dosing, cost, and safety data before deciding which (if either) makes sense.Updated 2026-07-26Read guide →
Epitalon vs rapamycin: what the longevity evidence actually showsEpitalon has small Russian human trials; rapamycin has decades of NIA-funded rodent data and off-label human use. Here's what each actually has behind it.Updated 2026-07-26Read guide →
Epitalon vs resveratrol: comparing the longevity evidenceEpitalon's telomerase claims come from a small Russian lab; resveratrol has broader but underwhelming human data. Here's how the evidence actually compares.Updated 2026-07-26Read guide →
Epitalon vs telomerase activators: what the evidence showsEpitalon and TA-65 both claim telomere effects, but human trial data is thin for both. Compare the actual research base, gaps, and what's known.Updated 2026-07-26Read guide →

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